Messi ran amok at Wembley Stadium, slicing Spurs apart with incisive passes from deep, such as the one that allowed Philippe Coutinho to open the scoring.
Real play Athletic Bilbao while Barcelona visit Real Sociedad in fixtures that have often proved to be among their hardest away trips over the last decade.
The Spanish Football Federation has settled on the single-game format for Sunday’s encounter between Liga champions and Copa del Rey holders, Barca and cup runners-up, Sevilla.
Ernesto Valverde rested Lionel Messi for his team’s penultimate match of the campaign, but it was a defensive horror-show that allowed Emmanuel Boateng to score a hat trick of his own and Enis Bardhi a brace at the City of Valencia Stadium
Zinedine Zidane's Real charges will be heading to Catalonia full of confidence having made it into the final of the Champions League, and will now be hoping to prevent Barca going the entire La Liga season unbeaten.
Ernesto Valverde's side are unbeaten in their 26 league games this season but though victory against their closest challengers would leave them eight points clear at the top, the Spaniard insists the showdown will not decide the title
Early goals from Luis Suarez and Lionel Messi calmed the nerves at the Nou Camp on Thursday
A thrilling second half to the El Clasico showdown in Catalonia saw Lionel Messi cancel out an earlier Gerard Pique own goal from the penalty spot, with the decision controversially given after Luis Suarez appeared to dive