Top seed Simona Halep became the latest high-profile casualty of the opening week of Wimbledon after losing to Hsieh Su-wei in three sets.
Halep saw a match point saved during a tense third set and, despite being broken seven times, it was the Taiwanese world No 48 who edged through 3-6 6-4 7-5.
The world No 1 was unable to avoid the same fate as her fellow pre-tournament favourites, including defending champion Garbine Muguruza and second seed Caroline Wozniacki.
Victory for Hsieh means Karolina Pliskova is the only member of the tournament’s top-10 seeds still in the draw at the All England Club.
After Halep started strongly to win the opener it was her 32-year-old opponent who responded well to force a deciding set.
Hiseh recovered from a 5-3 deficit and a match point in the 10th game to regain parity before she consolidated a break of serve with a tense hold to book a fourth-round meeting with Dominika Cibulkova, who defeated 15th seed Elise Mertens 6-2 6-2.