Under the management of Ralf Rangnick for the first time, Crystal Palace had threatened to claim a point in Manchester.
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Wan-Bissaka received a straight red card in the 35th minute of his side’s shock 2-1 loss earlier this month after a foul on Christopher Martins Pereira.
The Portugal international also became the first player to score the opening goal in two different Champions League campaigns, having previously scored the first goal for Real Madrid in a 5-2 win against FC Zurich during the 2009-10 season.
The result handed the Serie A side their first away defeat in a competitive match for over a year
A surprise slip up by Juventus away to Young Boys opened the door for the Red Devils to leapfrog them in the table but they were soundly beaten by the Spaniards
It looked as though the hosts were on course for a second successive goalless draw in front of their own fans following another dreary display, which failed to entertain a sparse Old Trafford crowd.
Manchester United scored twice in the final five minutes to seal a famous comeback victory over Juventus at the Allianz Stadium in Turin on Wednesday.
He bagged his first treble of the tournament in Tuesday evening’s match against Swiss side Young Boys.
Wolves make the trip to Old Trafford having put together a four-match unbeaten streak of their own in the league and EFL Cup, and Nuno Espirito Santo will relish the chance to go head to head with a manager in Jose Mourinho under whom he featured during his playing days
Manchester United have kicked off their 2018-19 Champions League campaign with a 3-0 win over tournament debutants Young Boys at the Stade de Suisse on Wednesday.
Smalling statement was on the club’s website “www.manutdfc.com” on Monday.