Up against 27th seed Anisimova, four-time Grand Slam champion Osaka never looked comfortable on her least favourite surface as she struggled to control her powerful game.
Browsing: Amanda Anisimova
The Japanese four-time Grand Slam champion, seeded 13, won the first set on Margaret Court Arena but the nerveless Anisimova saved two match points in the third to pull off a huge 4-6, 6-3, 7-6 (10/5) upset.
Teenage sensation, Amanda Anisimova, blew defending champion Simona Halep out of the French Open 6-2 6-4 in a quarterfinal shock on Thursday, setting her sights on the Suzanne Lenglen Cup in a wide open draw.
The 28-year-old Czech came into Indian Wells having won the last two tournaments she played in