As ever, this game could play a key role in determining the order of finishers at the top of La Liga, with both Los Blancos and the Blaugrana hungry to challenge Atletico Madrid in what has become a three-horse race for the title.
Browsing: Sergino Dest
Messi finally got his first assist of the season when he picked out defender Clement Lenglet with a splendid cross and the Frenchman rose to head FC Barcelona in front after 21 minutes.
Dest became the first US international to join Barca on Thursday, signing from Ajax Amsterdam on a long-term contract at the Camp Nou.