The Scot triumphed with an epic 6-3 6-3 4-6 6-7(7) 7-6 (10-6) win.
Browsing: Matteo Berrettini
Elsewhere on day two of the Championships, title contender Matteo Berrettini was forced to pull out with coronavirus.
Seventh seed Berrettini eventually turned the match into a contest, but Nadal completed a 6-3 6-2 3-6 6-3 win.
Djokovic, 34, of Serbia, beat Berrettini, 25, of Italy, to clinch his 20th Grand Slam singles title. The win ties him with Roger Federer and Rafael Nadal, who have also won 20 Grand Slam singles events.
His third straight triumph at the All England Club also earned the Serbian a 20th Grand Slam title, equalling the men’s record haul held by Switzerland’s Roger Federer and Rafa Nadal of Spain.
The 25-year-old from Rome became the first Italian man to reach the SW19 showpiece after a 6-3 6-0 6-7 (3) 6-4 victory.
World no. 3 in men’s singles, Nadal beat Argentine opponent Diego Schwartzman 3-1 with sets of 6-3, 4-6, 6-4, 6-0 in the quarterfinal match in Paris.
The 39-year-old Swiss prevailed 7-6 (7-5), 6-7 (3-7), 7-6 (7-4), 7-5 over Dominik Koepfer on Saturday night.
Zverev is looking for his first Masters title since he got the better of Thiem in the final in the Spanish capital three years ago.
But the three-time champion will also be defending the honour of the big-three in men’s tennis.