The Toffees dropped their first points of the campaign at home to Merseyside rivals Liverpool last weekend, while Southampton snatched a dramatic late 3-3 draw with Chelsea.
Browsing: St. Mary’s Stadium
The goals came either side of half-time from Moussa Djenepo and Oriol Romeu at St Mary’s Stadium.
Meanwhile, the Baggies travel to the South Coast as one of four clubs who are still looking for their first win in the Premier League this season.
The Blades are eighth in the table heading into this clash with Southampton, who have gone six games without defeat to climb into 12th.
Fresh from a magnificent victory over Premier League champions Liverpool, Manchester City continue their campaign with a trip to Southampton this evening.
Manchester United midfielder Jesse Lingard has withdrawn from the England squad and returned to his club due to illness.
Liverpool will switch their attention back to the Premier League this afternoon following their European exertions during the week with the Reds facing a trip to Southampton.
Manchester City have bounced back from successive defeats with a 3-1 victory over relegation-threatened Southampton at St Mary’s on Saturday.
Danny Ings twice gave the Saints the lead only for two Henrikh Mkhitaryan goals to get Arsenal back on level terms, but Charlie Austin headed home a late winner to hand Ralph Hasenhuttl his first win since his arrival at the club.
Arsenal make the trip to St Mary’s to face Southampton in the Premier League having put together a 22-match unbeaten run in all competitions.
Premier League strugglers Southampton and Newcastle will be hoping a win could spark their respective seasons into life when they meet at St Mary’s this afternoon.
The Belgium international urged fans “to move on” from repeating the chant, which anti-discrimination group Kick It Out suggested was “offensive and discriminatory” due to its racial undertones.
With just one victory from five, Ronald Koeman’s men will be keen to register a morale-boosting win and set off on the road to prove that they are not a one-season wonder