The Cottagers’ fate was confirmed with defeat at home to Burnley on Monday, while Southampton beat Crystal Palace last time out to climb up to 14th place.
Browsing: St. Mary’s Stadium
The Clarets, meanwhile, are looking to secure back-to-back away league wins for the first time since July 2020.
The clubs are meeting for the second time in three days after the Saints prevailed in the FA Cup fifth round on Thursday night.
The sides are locked on the same number of points heading into this evening’s clash, though Villa have played a game fewer than Southampton.
The Citizens are eight points adrift of leaders Liverpool with a game in hand, while Southampton are four points better off in third after a superb start to the campaign.
The Blades are without a win in 11 matches this campaign and are bottom of the division, while the Saints returned to winning ways last time out to climb into sixth place.
The Red Devils travel to St Mary’s on a three-game winning streak in all competitions, but they face a tough test against a Southampton side unbeaten in seven.
The Toffees dropped their first points of the campaign at home to Merseyside rivals Liverpool last weekend, while Southampton snatched a dramatic late 3-3 draw with Chelsea.
The goals came either side of half-time from Moussa Djenepo and Oriol Romeu at St Mary’s Stadium.
Meanwhile, the Baggies travel to the South Coast as one of four clubs who are still looking for their first win in the Premier League this season.
The Blades are eighth in the table heading into this clash with Southampton, who have gone six games without defeat to climb into 12th.
Fresh from a magnificent victory over Premier League champions Liverpool, Manchester City continue their campaign with a trip to Southampton this evening.
Manchester United midfielder Jesse Lingard has withdrawn from the England squad and returned to his club due to illness.
Liverpool will switch their attention back to the Premier League this afternoon following their European exertions during the week with the Reds facing a trip to Southampton.
Manchester City have bounced back from successive defeats with a 3-1 victory over relegation-threatened Southampton at St Mary’s on Saturday.
Danny Ings twice gave the Saints the lead only for two Henrikh Mkhitaryan goals to get Arsenal back on level terms, but Charlie Austin headed home a late winner to hand Ralph Hasenhuttl his first win since his arrival at the club.
Arsenal make the trip to St Mary’s to face Southampton in the Premier League having put together a 22-match unbeaten run in all competitions.
Premier League strugglers Southampton and Newcastle will be hoping a win could spark their respective seasons into life when they meet at St Mary’s this afternoon.
The Belgium international urged fans “to move on” from repeating the chant, which anti-discrimination group Kick It Out suggested was “offensive and discriminatory” due to its racial undertones.
With just one victory from five, Ronald Koeman’s men will be keen to register a morale-boosting win and set off on the road to prove that they are not a one-season wonder