The Cottagers’ fate was confirmed with defeat at home to Burnley on Monday, while Southampton beat Crystal Palace last time out to climb up to 14th place.
The Reds have won just one of their last five games in all competitions, drawing the last three in succession, and they face a Saints side who are looking to complete the league double against them for just the third time in their history, previously doing so in 1960-61 and 2003-04.
The Saints had Jannick Vestergaard sent off early on, but managed to take a shock lead in the second half.
The clause was inserted in the deal that took him to the Foxes in 2017 and after struggling to find his feet, the 24-year-old is presently one of the hottest strikers in the English Premier League.
Iheanacho has 14 goals in 30 appearances for the Foxes this season, having netted 10 last term and just two in 2018-19.
The striker went 12 months without scoring but is now looking to fire the Foxes to the FA Cup final.
Ralph Hasenhuttl’s side moved 10 points clear of the relegation zone with eight games left after a dramatic fightback at St Mary’s.
The Clarets, meanwhile, are looking to secure back-to-back away league wins for the first time since July 2020.
Ralph Hasenhuttl’s men parked their Premier League problems as this competition once again provided a welcome distraction and shot in the arm for Saints.
The Cherries advanced to the last eight courtesy of a 2-0 success at Burnley in the previous round, whereas Southampton also prevailed 2-0 at fellow Premier League outfit Wolverhampton Wanderers.
On Saturday, Man City will seek to maintain their winning streaks as they are away to Everton at 6:30pm.
A first win in 10 matches stopped Saints’ alarming slide and moved them 10 points clear of the bottom three.
The Blades managed to return to winning ways with a 1-0 triumph over Aston Villa in midweek, while Southampton have had five days to recuperate from their dampening defeat at Everton by the same scoreline.
Takumi Minamino’s fine finish put Southampton ahead at the break and Ralph Hasenhuttl’s men held on for a morale-boosting point.
The Blues have picked up maximum points from their last four league matches to move into fourth position in the table, while Southampton have dropped to 13th following six straight losses in England’s top flight.
All matches scheduled for February 19 to 22 will be shown live on SuperSport.
The 87-cap Nigeria international has been without a club since he left Saudi Arabian outfit Al Nassr in 2020.
The clubs are meeting for the second time in three days after the Saints prevailed in the FA Cup fifth round on Thursday night.
It’s claimed that Musa was invited to West Bromwich Albion by Sam Allardyce, and he looked set for a move to the Baggies after undergoing a medical.
For the second time in as many seasons, the Saints found themselves on the wrong end of the Premier League’s biggest-ever scoreline, but this afternoon they take on a Newcastle side in even worse form.