The Brazil star was stretchered from the pitch in tears after suffering the injury in the final minutes of Sunday’s 3-1 victory at Saint-Etienne.
The Brazilian striker screamed in pain and was clutching his left ankle which appeared to give way following a challenge from Yvann Macon.
The 29-year-old represented Brazil at the 2014 World Cup on home soil and in Russia four years later.
The Argentine, who signed on a free transfer from Barcelona this summer, found the net with a trademark effort midway through the second half after Idrissa Gueye’s eight-minute strike had opened the scoring.
Ronaldo, 36, rejoined United from Juventus in August after 12 years away, while Messi has swapped boyhood club FC Barcelona to join Paris St Germain.
Messi hit the crossbar during his 150th appearance in the competition but could not score for his new club after PSG coach Mauricio Pochettino sent out his three superstars all together for the first time.
The Catalans, along with Real Madrid and Juventus are the only three clubs remaining in the seemingly doomed breakaway competition
The two parties had been in dispute since Neymar left Barca for Paris Saint-Germain in 2017.
Argentina had been Copa runners-up at four of the past seven tournaments, losing to rivals Brazil in 2004 and 2007
Brazil take on Argentina in the decider at the Maracana in Rio de Janeiro, with both players pursuing their first-ever continental crowns.
It was a ninth straight win for the Selecao who top Group B with a perfect six points from two games, while Peru fell to the bottom.
The hosts took the lead in the 23rd minute when Richarlison’s angled header from a Neymar corner-kick fell into the path of Marquinhos.
Argentina and Colombia were meant to co-host the event but were removed for Coronavirus reasons and political instability with Brazil stepping in at short notice.
The apparel giant said in a statement that its investigation into the alleged 2016 incident – which was reported to the company in 2018 – was inconclusive.
Without the suspended Neymar, PSG relied on Mbappe in Paris and the former Monaco prodigy delivered with an assist for Mauro Icardi’s opener before rounding off the win himself late on
Mauricio Pochettino’s side will go into next weekend’s final round of the season against Brest one point behind leaders Lille, who were held to a 0-0 draw by Saint-Etienne.
The 29-year-old said “happiness” was the main factor in signing a new deal.
The Brazilian claimed he was ready to “die on the pitch”.
After leading the London side to the semi-finals with a 2-1 aggregate victory over FC Porto, Tuchel is keeping his fingers crossed.
Neymar was sent off when he picked up a second yellow card for shoving Tiago Djalo, who reacted with a foul-mouthed rant and was also shown a red card, as Lille leapfrogged PSG to grab a three-point lead in Ligue 1.