Tottenham Hotspur gained sweet revenge over north London rivals Arsenal as goals in each half by Son Heung-min and Dele Alli earned them a 2-0 win on Wednesday.
Eintracht had already comfortably taken top spot in the group, thanks to winning all five of their previous games, while Lazio were also in the last 32 regardless of the result of the match
Manchester United manager, Jose Mourinho, expects a difficult test against Arsenal in the Premier League on Wednesday.
Arsenal's Europa League match against Vorskla Poltava on Thursday is in doubt after the Ukrainian side said they could not guarantee they would be able to fulfil the fixture.
Welbeck, often used as a backup striker by Manager Unai Emery, underwent two operations after suffering a broken ankle against Sporting Lisbon in the Europa League earlier this month.