The Belarussian, who moaned about the cold and damp conditions in her opening round win, capitulated in feeble fashion against her 161st-ranked opponent.
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The 40-year-old, playing in her 87th Grand Slam, fought hard but ultimately could find no way past her younger opponent as she suffered a third straight first-round loss at Roland Garros.
With a chill wind blowing and drizzle falling on the Simonne-Mathieu arena, the 40-year-old Williams began strongly but got bogged down in a baseline battle on a slow surface.