Chelsea will host Manchester City in the FA Cup fifth round following the draw on Sunday.
The encounter between Chelsea and Manchester City is the biggest at this stage of the competition.
League One side, Shrewsbury Town, the lowest ranked side remaining, will welcome Manchester United to the New Meadow.
Holders, Arsenal, will take on Hull in a repeat of the 2014 final, while Crystal Palace visit Tottenham and Bournemouth host Everton in two all-Premier League clashes.
The ties will be played on the weekend of February 19 to 22.
Full fifth-round draw
Chelsea v Manchester City
Reading v West Brom or Peterborough
Watford v Leeds United
Shrewsbury Town v Manchester United
Blackburn v Liverpool or West Ham
Tottenham v Crystal Palace
Arsenal v Hull
Bournemouth v Everton
