Wolves know that a win today would guarantee 12th position in the Premier League table, while Man United will end the 2020-21 campaign in second spot regardless of the result at Molineux.
The Blades are 18 points adrift and it will be mathematically impossible for them to escape the drop should they lose at Molineux and Newcastle United beat West Ham United.
Brendan Rodgers’ side would have gone level with Manchester United in second with victory but were forced to settle for a 0-0 draw at Molineux.
Meanwhile, the home side head into the contest at Molineux on the back of a much-needed 2-1 win against Arsenal, a result which has moved the club 12 points clear of the relegation zone.
While the home side have gone five matches without recording maximum points, the Baggies last recorded success on November 28 when they edged out bottom-placed Sheffield United.
Spurs have lost their last two in the league to Liverpool and Leicester City, which has seen them drop down into eighth position in the table, while Wolves currently occupy 11th position.
Currently sitting in second, the Foxes are just a point behind leaders Liverpool heading into the weekend, while Wolves are only two points further down the table in sixth.
The 20-year-old Portugal Under-21 international has scored six goals in 52 appearances for the club since joining from Lazio last summer.
Nuno Espirito Santo’s side go into the game off the back of successive 1-0 wins over newly-promoted duo Fulham and Leeds United, whereas Newcastle were beaten 4-1 at home by Manchester United last time out.
The Cottagers travel to the West Midlands having already suffered 3-0 defeats to Aston Villa and Brentford this week, piling the pressure on manager Scott Parker.
Meanwhile, despite registering eight points from five games since the resumption, the Toffees remain in the bottom half of the standings.
Diogo Jota struck twice as Wolverhampton Wanderers pushed Norwich City deeper towards the drop with a 3-0 win over the English Premier League’s bottom club at Molineux on Sunday.
Wolverhampton Wanderers saw their impressive English Premier League campaign run into the buffers on Wednesday at home.
Wolves are leading the chase for Tammy Abraham as he prepares to cut short his loan spell with Aston Villa.
The playoff fight looks likely to go down to the wire with seven clubs struggling for the two remaining slots alongside Aston Villa.
“The support you’ve shown me has been incredible,” said Ikeme in a video message played at Molineux before Saturday’s 1-0 win over Middlesbrough.
Tributes have poured in from across the footballing world for the 31-year-old – and now the huge footballing challenge is set to take place before the first home game of the season against Middlesbrough on August 5.