The high-flying Hammers are currently third in the table, three points behind leaders Chelsea, while Wolves occupy eighth position, just one point off sixth-placed Manchester United.
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Bruno Lage’s side marched to a 1-0 victory over Southampton in gameweek six, whereas the Magpies could only draw 1-1 away to Watford.
Jimenez feared he would never play again after suffering a fractured skull in a clash with David Luiz at Arsenal last autumn.
Bruno Lage’s side, who sit 13th in the table, recorded a 2-0 win over Watford in their last league encounter, while 10th-placed Brentford suffered a 1-0 home defeat to Brighton & Hove Albion.
Watford suffered a 1-0 loss to Tottenham Hotspur before the international break, while Wolves, who are yet to get off the mark this term, were beaten 1-0 by Manchester United at Molineux.
Ole Gunnar Solskjaer will oversee his 100th Premier League match in charge of the Red Devils and history could also be made, just days after the 20-time champions pulled off a sensational deal to bring Cristiano Ronaldo back to the club.
While Brendan Rodgers is gearing up for his third full season in charge of the Foxes, a new name will aim to restore Wolves back to their short-lived European days.
The 28-year-old’s arrival at Molineux comes after Wolves’ first-choice keeper Rui Patricio completed a move to Roma.
Wolves, meanwhile, still have an outside chance of finishing in the top half for a third successive season.
However, Brighton, who have all but avoided relegation with four games to spare, make the trip to Molineux sitting just five points adrift of their hosts
Wolves, meanwhile, will be aiming to extend their winning run to three matches.
The Blades are 18 points adrift and it will be mathematically impossible for them to escape the drop should they lose at Molineux and Newcastle United beat West Ham United.
The Premier League club will then be in position to introduce safe standing should any change in UK law occur.
The clubs are meeting for the second time in three days after the Saints prevailed in the FA Cup fifth round on Thursday night.
Brendan Rodgers’ side would have gone level with Manchester United in second with victory but were forced to settle for a 0-0 draw at Molineux.
Meanwhile, the home side head into the contest at Molineux on the back of a much-needed 2-1 win against Arsenal, a result which has moved the club 12 points clear of the relegation zone.
“It’s been a long time coming,” he said in his post-match interview. “We work hard all the time and it’s not come off for us, but today it worked so I’m grateful.
Wolves had knocked Palace out of the cup by the same scoreline when they met earlier this month.
Palace will enter today’s contest off the back of a 3-2 home defeat to West Ham United on Tuesday, while Wolves held Thomas Tuchel’s Chelsea to a goalless draw at Stamford Bridge on Wednesday.
The German, who replaced Frank Lampard on Tuesday, watched his side create 14 shots on goal but saw them unable to find the breakthrough