The multiple grand slam champions were due to begin their partnership against Andreas Mies and Alexa Guarachi on Centre Court.
The defending champion dropped a set for the first time at the Championships to the 6ft 5in Pole, losing a tie-break in the second
The eight-time Wimbledon champion, who is chasing a 21st major crown, unleashed 46 winners past the battling world number 169.
The defending champion arrived on Centre Court later than anticipated, following Kyle Edmund’s five-set defeat against Fernando Verdasco, and he made light work of his American opponent to seal a 6-3 6-2 6-2 win in one hour and 33 minutes.
Gauff, the youngest player to reach the Wimbledon women’s singles main draw via qualifying and the youngest to win a round since 1991, gave the 30-year-old former semi-finalist a torrid time as her fairytale debut continued under the Court One roof.
The 39-year-old Williams has won the singles title five times, including twice before Gauff was born, but was bullied into submission by the schoolgirl.
Novak Djokovic got the defence of his Wimbledon title off to an impressive start when serving superbly, he overwhelmed Germany’s Philipp Kohlschreiber in straight sets in the first match on Centre Court on Monday.
The world number two was edged out in the first-set tiebreak and never recovered, suffering a double break in the second set before going down 7-6, 6-2.
Ivanisevic, who became the only man to win the men’s singles as a wild card in 2001, will work with Djokovic for the first week of Wimbledon.
Serena Williams ignited talk of a dream-team partnership with home favorite Andy Murray after declaring her availability for the Wimbledon mixed doubles on Saturday.
Eight-time Champion Roger Federer was confirmed as the second seed for Wimbledon on Wednesday, bumping Rafael Nadal down to third in spite being ranked below the Spaniard.
Andy Murray is looking to make a comeback to the tennis circuit and possibly play doubles at Wimbledon after he revealed he is now pain free following hip resurfacing surgery.
Two-times Wimbledon champion Petra Kvitova told a Czech court on Tuesday how she grabbed the blade of an attacker’s knife and forced it away from her neck, leaving blood everywhere, during an attack at her home in December 2016.
Murray, who became the first British player in 77 years to win the men’s singles title at the All England Club in 2013, is retiring from tennis this year due to continuing pain in his hip.
The move will prevent a repeat of the marathon matches that have previously occurred at the tournament, including the world-record match between John Isner and Nicolas Mahut in 2010 that reached 70-68 in the final set and lasted over 11 hours
Reigning Wimbledon champion Angelique Kerber has split from coach Wim Fissette, the player’s entourage announced Tuesday.
The former world number one returned to the Association of Tennis Professional tour in June after having hip surgery in January and has played nine competitive matches this year.
Williams, who made the Wimbledon final last month but withdrew from last week’s Rogers Cup in Montreal for personal reasons, cracked eight aces and was never broken as she dispatched the 24-year-old Australian.
The Wimbledon runner-up withdrew from the Montreal tournament on Saturday citing “personal reasons”
The 23-time Grand Slam champion took to Twitter on Wednesday after she received another visit from a tester.