La Bluagrana were on the front foot from the start in Italy, with former Juventus star Miralem Pjanic testing Wojciech Szczesny and Antoine Griezmann firing against the post inside the first five minutes
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Goals from Diogo Jota and a Mohamed Salah penalty kick secured victory for the 2018/2019 champions.
Manchester City took control of Group C with six points from two games, leading FC Porto and Olympiakos by three points while OM are bottom of the table after two defeats.
Midfielder Fabinho has been filling in for Van Dijk in the centre of defence since the Dutchman suffered a serious knee injury in the Merseyside derby against Everton.
At the Wanda Metropolitano stadium, Marcos Llorente put Atletico Madrid ahead in the first half.
The result ensured that the Spanish champions snapped a three-game losing run in the competition.
In this their UEFA Champions League Group D clash, the Colombian international’s double came after defensive lapses had allowed the Dutch to go 2-0 ahead at the interval.
PSG thus moved top of the Ligue 1 standings
The match was played in driving rain at the MCH Arena in Herning on Wednesday.
The win stretched Bayern Munich’s winning run in the competition to 12 games.
The Austrian champions were leading 2-1 and completely in control, only to be pegged back by an equaliser from substitute Vitali Lisakovich.
The Belgian put Inter Milan in front with an opportunist goal in the 49th minute.
Their second strike was credited as an own goal by goalkeeper Marwin Hitz.
It was the first 0-0 draw for Chelsea since Lampard took charge before last season.
In their Group G opener at the Camp Nou on Tuesday, Messi netted from the penalty spot in the first half for his 116th career goal in the competition.
After a cagey opening to the clash, a delicious Bruno Fernandes first-time through ball to the alert Marcus Rashford almost produced the game’s opener.
Dennis gave Brugge the lead in the 63rd minute after keeping the ball in play on the right touchline and feeding it into the box for De Ketalaere to hit a shot blocked on the line by Yaroslav Rakitskyy.
The result sent the Hungarian side through on away goals following a 3-3 draw in Norway.
Guardiola said this was because Aguero was yet to train with the club since suffering a knee injury in June
PAOK’S reward is a two-legged play-off against Russians Krasnodar, while Dynamo Kiev face Gent for berths in the money-spinning group stage featuring 32 teams