The Premier League fixture will still go ahead as planned on Sunday evening, the club have confirmed, however.
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The 87-cap Nigeria international has been without a club since he left Saudi Arabian outfit Al Nassr in 2020.
The Republic of Ireland midfielder was ordered off five minutes into the second half for a needless second yellow card after tugging the shirt of Takumi Minamino, the Liverpool loan midfielder who struck a stunning debut goal to halve Southampton’s deficit before the break.
Willock, an England Under-21 international, will spend the rest of the season on Tyneside as part of Steve Bruce’s squad.
Wilson headed in a right-wing corner in the 73rd minute before slotting home a finish on the counterattack in stoppage time to hand Newcastle its first victory in the league since December 12.
The Magpies have lost their last five in England’s top flight to drop into 16th position in the table, while Everton currently occupy seventh, two points behind fourth-placed West Ham United as things stand.
The Gunners were facing an unlikely battle for survival less than a month ago, but 13 points from a possible 15 have lifted Mikel Arteta’s men into 10th and within seven points of the top four.
Juergen Klopp’s side had the chance to open up a five-point lead at the top of the table, but a combination of wastefulness and Newcastle’s valiant rearguard kept them at bay
The news comes after Kyle Walker, Gabriel Jesus and two City staff members returned positive tests, missing the Boxing Day win over Newcastle.
The victory lifted City to fifth in the English Premier League on Saturday
Newcastle asked the Premier League to cancel the game on public health grounds with the squad hit by more than five positive tests, and uncertain how many more could develop.
Frank Lampard’s side would jump from fifth to first with victory in the opening match of gameweek nine, but they have struggled at this venue in recent seasons.
Pickford was rested by manager Carlo Ancelotti after a turbulent few weeks, but replacement Robin Olsen could not keep out Wilson’s 56th minute penalty and his late second to prevent a much-changed Toffees’ side from slipping to a 2-1 defeat at St James’ Park.
After a frustrating afternoon of trying to break down Newcastle’s defence, Raul Jimenez gave Wolves the lead in the 80th minute.
The French winger signed an initial six-year deal when he signed for £16 million from Nice last summer, but has now agreed on an additional year and bumper pay rise.
While Spurs recorded a ruthless 5-2 win at Southampton, Newcastle’s three points came from a 2-0 victory at West Ham United on the first weekend of the campaign.
Crystal Palace are keen on the player as well.
The game began with a minute’s silence to mark the passing of former Newcastle and Ireland manager Jack Charlton, who won the World Cup with England as a player, after he died on Friday aged 85
Steve Bruce’s side made the most after Blades defender John Egan’s second half dismissal at empty St James’ Park
While the Magpies have not fared much better, picking up two points over the same period has kept the club above Palace in the table