The 20-time grand slam champion, who won his fourth Flushing Meadows title two years ago, is still troubled by the foot injury he aggravated at the French Open.
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The four-time winner at Flushing Meadows does not want to travel to the United States for the event, which begins on August 31, while COVID-19 cases are on the rise.
Rafael Nadal came through his first stern examination at the US Open to move a step closer to a maiden Flushing Meadows meeting with Roger Federer.
Defending US Open champion Sloane Stephens was dumped out in the quarterfinals after losing 6-2 6-3 to Latvian 19th seed Anastasija Sevastova in sweltering conditions on Tuesday.
Defending champion, Sloane Stephens, eased into the quarterfinals of the US Open with a 6-3, 6-3 victory over Belgian Elise Mertens on Sunday.
The 23 Grand Slam winner was literally on fire against her sister, merciless in her blistering returns and making Venus look more like her apprentice
Roger Federer heads to the US Open as third favorite behind longtime rivals Novak Djokovic and Rafael Nadal after a season that has nose-dived since he won the Australian Open at the start of the year.
Jo-Wilfried Tsonga has been forced to withdraw from the US Open after failing to recover sufficiently from knee surgery.
The Spaniard, who has won the Grand Slam at Flushing Meadows twice before, sealed a 6-2 6-4 6-1 victory in one hour and 42 minutes