Man United are currently fourth in the table, one point behind leaders Liverpool, while Rafael Benitez’s Everton occupy fifth, level on points with their opponents at Old Trafford.
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The two clubs also enter the contest on the back of top-flight losses, as Rafael Benitez’s side went down 3-0 to Aston Villa while the Canaries also shipped three against Watford.
Rodriguez has been in the Middle Eastern nation for transfer talks as he looks to leave the Toffees one year after joining from Real Madrid.
James is currently in Doha to discuss a move to the Qataris.
Okoronkwo, who celebrated his 17th birthday on Saturday, will link up with Paul Tait’s Everton Under-18s side having agreed a professional contract with the Blues until the end of June 2024.
The Toffees marched to a 3-1 success against Burnley in their most recent encounter, while Dean Smith’s side fell victim to a Romelu Lukaku-inspired Chelsea in a 3-0 defeat.
The midfielder endured fitness problem during last month’s Carabao Cup clash with Huddersfield but impressed the Blues boss with his resilience.
The striker comes in for Juve as a replacement for the outgoing Cristiano Ronaldo, who is set to return to Manchester United.
Everton striker Dominic Calvert-Lewin has withdrawn from the England squad because of a thigh injury.
The Seagulls are currently fourth in the table on six points, while Everton have also made an encouraging start, collecting four points from their two fixtures under Rafael Benitez’s leadership.
An Everton side featuring nine changes from the side that were held to a 2-2 draw at Leeds at the weekend looked to be up against it when Iwobi’s goal was cancelled out by Tom Lees before Kean was given his marching orders.
The Brazilian winger crashed home a second-half equaliser – his third goal in as many games against the Toffees – as Leeds twice hit back to earn their first point of the new campaign.
The Whites found it difficult against Ole Gunnar Solskjaer’s side in their season opener, but Everton started life under Rafael Benitez with an impressive 3-1 victory over Southampton at Goodison Park.
The Spaniard, famous for a rather more high-profile comeback with the red half of the city in 2005, has plenty of work to convince the doubters he can ever be accepted at Goodison Park, but this was as good an opening as he could have wished for.
The Toffees will seek to sustain a European charge this term, while Southampton will aim to condemn the second half of their 2020-21 season to history.
It was claimed that the Serie A club is still looking at the Premier League, with Iwobi a potential target.
The 22-year-old Nigeria international is extremely highly rated and won’t be available on the cheap.
The 25-year-old former Leicester winger has signed a three-year deal and has the option of a fourth with the Toffees as he leaves German side Bayer Leverkusen for an undisclosed fee after just six months in the Bundesliga.
The 61-year-old Spaniard has signed a three-year deal and succeeds Carlo Ancelotti, who resigned in early June to return to Real Madrid.
Ancelotti managed Real from 2013 to 2015, leading them to their 10th European Cup triumph against Atletico Madrid in Lisbon in 2014.