The Brighton of England new signing, according to camp sources, picked a knock in training and may be left out of the starting team against Croatia.
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The 29-year-old left Bundesliga side Mainz at the end of the season and has signed a two-year deal with the Seagulls.
The Foxes won 2-0 at Brighton on Saturday but the victory came at a cost as Ndidi was dismissed for a second bookable offence three minutes from time.
The England midfielder missed Thursday’s 3-0 home defeat to Manchester City with a minor ankle issue and could also sit out the game on the south coast
Two goals inside the opening six minutes put us well in control against the Seagulls, with Eden Hazard giving us the lead after just three minutes, before the second was finished emphatically by Willian after a stunning team build-up.
Arsenal are unbeaten in their last 31 Premier League matches against newly-promoted sides (W26 D5), collecting 83 points from a possible 93 since losing 1-2 to QPR in March 2012
The Nigeria international has been tracked by Tottenham, Liverpool and West Bromwich Albion in recent months but Brighton have made their move only for Gent to value him at £13m.
The 19-year-old, who scored 26 goals on loan at Championship side Bristol City last season, announced his new deal on Twitter – although moments later the message was deleted
The match would have sealed the team’s promotion
Ikeme has sat out the last three games with a hamstring injury he picked up while on international duty with Nigeria
And after his Nigerian international teammate, John Mikel Obi, sealed a move to Tianjin TEDA last week, Ighalo may follow him to the Far East