Brighton’s French forward Georginio Rutter put the visitors ahead in the seventh minute before 22-year-old Palmer’s 11-minute hat-trick.
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After Brighton rejected a succession of bids from Chelsea, it remains to be seen whether the Blues will now match that amount.
Head coach Roberto De Zerbi has expressed his desire to keep hold of Colwill, who enjoyed a successful season-long loan spell with the Seagulls in 2022-23, featuring 20 times in all competitions including 13 Premier League starts.
The former Rangers defender left Ibrox for Dutch giants Ajax back in July last year in a record £22.6million sale for the Scottish Premiership club.
The 64-year-old ex-defender had been working as a technical adviser for the team since February last year.
The visitors were cruising at 3-0 thanks goals by Bukayo Saka, Martin Odegaard and Eddie Nketiah before Kaoru Mitoma pulled one back
He became ill last month on a flight to join the Zambia national team squad in Mali and was treated in a hospital there.
Spurs suffered a derby defeat at rivals Arsenal last Saturday but worse news was to follow on Thursday when it was announced that club fitness coach Gian Piero Ventrone had died at the age of 61.
Newcastle has a war chest to dip into after being taken over by the Saudis in January and are investing significant cash into the club.
Some players will reportedly see their weekly salaries drop by up to 25 per cent next season after a deeply disappointing campaign at Old Trafford.
Graham Potter’s side humbled Wolverhampton Wanderers at Molineux last weekend, while the Red Devils enjoyed a confidence-boosting success over Brentford.
The hosts will be looking to claim back-to-back league victories on home soil for the first time since November.
Liverpool stormed to the top of the table by tearing Manchester United to shreds in a 4-0 win at Anfield on Tuesday.
Conte tested positive at the weekend and has subsequently been distancing in order to avoid spreading the virus.
The Seagulls went down 2-1 to Newcastle United last time out, while Jurgen Klopp’s side sealed their spot in the quarter-finals of the Champions League in midweek.
Seeking to extend their unbeaten Premier League run to seven games and move further away from the relegation zone, Newcastle United play host to Brighton & Hove Albion this afternoon.
The Hornets went down 1-0 to West Ham United in midweek, while Graham Potter’s men have not been in action since bowing out of the FA Cup to Tottenham Hotspur last week.
Bissouma was named by the Mali coach Mohamed Magassouba on Friday in a 28-man squad for the tournament that kicks off in Cameroon on 9 January.
Meanwhile, Brentford have collected two victories from their last four outings, leaving the Bees level on points with their hosts in the Premier League standings.
The hosts drew 2-2 with Leicester City in midweek, while the Seagulls make the journey across the South Coast after taking a point home from West Ham United.