Alexandre Lacazette’s stretching volley gave Arsenal the lead in the 14th minute but Ayoze Perez clipped in Newcastle’s equaliser on the half hour mark.
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The Magpies have lost just once since January to climb into the top half of the table, 10 points clear of the relegation zone and just two short of the magic 40 mark
The Saints are three points from safety with six games left to play
The Gunners survived a scare to eventually beat CSKA Moscow 6-3 on aggregate in the quarter-finals and will now take on Atleti in the toughest possible semi-final draw.
The Egypt international was dismissed for raising his hands in a confrontation with Saints defender Cedric Soares in stoppage time at the Emirates Stadium.
The match ended on a chaotic note as Stephens saw red for lashing out at Jack Wilshere, who himself earned a yellow card for his part in an injury-time scuffle, while Mohamed Elneny was also sent off for a shove on Soares
The Gunners, fresh from a solid result in the Europa League, face up against a Southampton side who are craving a win to ignite their Premier League survival push
The Welshman and the French striker will likely take most of the plaudits following a resounding win at the Emirates, although Mesut Ozil was the unsung hero as he played a crucial part in all four goals to help hand the Gunners a commanding lead going into the second leg.
Ndidi has already been linked with Liverpool over the last few days and The Sun claims that Arsenal are now monitoring the player.
Stoke went into the game having not won since January 20
The midfielder joined from Swiss champions Basel in January 2016 and has since made 66 appearances in all competitions, scoring two goals.
The French striker has been sidelined since mid-February after undergoing an operation to correct an ongoing issue with his left knee.
The Red Devils, who topped Deloitte’s Money League in January for the world’s richest clubs, also came out top of the Social Network Rankings for the English Premier League in 2017
Watford also suffered defeat last weekend as they went down 3-0 at Arsenal, and back-to-back away trips to top-six opposition will be a test of how far they have come under new manager Javi Gracia.
The Gunners, who progressed in the competition thanks to a 5-1 aggregate victory over AC Milan, avoided a nightmare draw against Atletico Madrid, who were instead paired with Sporting Lisbon
The World Cup-winning defender said in an interview with German publication Der Spiegel that his “body was finished” and that he would rather sit on the bench or in the stands.
A controversial penalty from Danny Welbeck followed by Granit Xhaka’s second-half strike proved enough to nullify a surprise opener from Hakan Calhanoglu in north London, before Welbeck returned to bag a brace late on as Arsene Wenger’s men secured a 5-1 win on aggregate.
Aubameyang, who joined Arsenal in January, played for former club Borussia Dortmund in the UEFA Champions League this season.
Troy Deeney missed a second-half penalty to get Watford back in the game as Petr Cech became the first goalkeeper to reach 200 Premier League clean sheets
Victory over Gennaro Gattuso’s side saw Wenger’s men end a four-match losing streak, which had previously seen the Gunners lose to Ostersunds FK, Manchester City twice and then against Brighton & Hove Albion last time out in the league