Serie A leaders Napoli came agonisingly close to pulling off a dramatic Europa League comeback when they won 2-0 at RB Leipzig, but went out on away goals at the last 32 stage on Thursday.
The Italians lost 3-1 at home in last week’s first leg with a performance that embarrassed coach Maurizio Sarri, although he has emphasised that winning Serie A is the priority.
They restored some pride in the return as Piotr Zielinski scored from a rebound in the 33rd minute and Lorenzo Insigne turned in Jose Callejon’s cross with five minutes to go.
That set up a rousing finale and Callejon could even have won the tie in stoppage time but his shot sailed over.
Lazio striker Ciro Immobile scored a hat-trick to lead his side to a 5-1 win over FCSB, formerly Steaua Bucharest, after a 1-0 defeat in the first leg.
Igor Denisov’s first-half goal gave Lokomotiv a 1-0 win over Nice, completing a 4-2 aggregate victory, while Zenit beat Celtic 3-0 to go through 3-1 with goals from Branislav Ivanovic, Daler Kuzyaev and Aleksandr Kokorin.
“We dominated the game. We didn’t concede any chances until the 70th minute,” said Zenit coach Roberto Mancini after a match which kicked off in a temperature of minus 13 Celsius.
“After 70 minutes we tired a bit but this is normal, but in the end we deserved to win.”
Atletico Madrid, leading 4-1 from the first leg, completed the formality at home to FC Copenhagen when Kevin Gameiro’s early goal gave them a 1-0 win.
Meanwhile Dynamo Kiev, Sporting, Viktoria Plzen and Olympique Lyonnais also reached the last 16.