Chelsea suffered a huge setback in their fight for Champions League football with 1-2 loss to Southampton.
Arsenal and Tottenham both won as the London trio continue their battle for a top-four finish.
Chelsea are in great danger of missing out on Champions League football next season after they came away from Southampton with a 2-1 defeat, following Rafael Benitez’s decision to rest star names for Monday’s FA Cup quarter-final replay with United.
Jay Rodriguez and Rickie Lambert were on the scoresheet for Saints, leaving Chelsea only two points clear of fifth-placed Arsenal.
Benitez excused Eden Hazard, Juan Mata and Demba Ba from his starting XI as he left one eye on the Cup, and Chelsea were punished when Rodriguez exchanged a one-two with Steven Davis before slotting past Petr Cech.
John Terry capitalised on poor Southampton marking to equalise at a corner, but within two minutes, Lambert restored Saints’ lead prior to half-time, slamming home a wonderful free-kick.
Chelsea searched desperately for a route back into the match but Hazard fired agonisingly wide with one of their better efforts, as Saints moved four points clear of danger.
Arsenal capitalised as they welcomed a Reading side guided by new boss, Nigel Adkins, to Emirates Stadium, chalking up a 4-1 victory without England internationals, Jack Wilshere and Theo Walcott.
Defeat, which was inflicted by Gervinho, Santi Cazorla, Olivier Giroud and Mikel Arteta, leaves the Royals seven points from safety with only another seven games to play.
Victory for Arsenal keeps them within four points of third-placed Tottenham with a game in hand after Spurs beat Swansea 2-1 at the Liberty Stadium.
Manchester City maintained their faint hopes of a title defence, with a thumping 4-0 win over Newcastle at the Etihad Stadium.
Goals from Carlos Tevez, David Silva and Vincent Kompany – in addition to a James Perch own goal – returned the gap at the top to 15 points.
At the bottom, Wigan are in the mood for another great escape after they beat Norwich 1-0 at the DW Stadium.
In the day’s other 3pm kick-off, West Ham eased any fears they might have had about relegation with a 3-1 victory over West Brom.
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