Atletico Madrid failed to break down Real Betis in a 0-0 draw on Sunday, which further reduced their slim chances of catching FC Barcelona at the top of La Liga.
Elsewhere, Las Palmas were relegated after a crushing 4-0 home defeat by Alaves.
Diego Simeone’s Atletico moved 11 points behind FC Barcelona with four games remaining and the unbeaten leaders need one more point to win the title.
With the Europa League semi-final first leg match at Arsenal on Thursday in mind, Simeone rotated key players and Betis tried to take advantage.
Javi Garcia missed two excellent chances and Cristian Tello struck the post for the visitors, who extended their club record run of games without conceding a goal to six.
However, Atletico’s defensive resilience ended Betis’ run of six wins in a row as they recorded their 11th consecutive home clean sheet.
Aissa Mandi headed a Fernando Torres effort off the line and Saul Niguez struck the bar as Atletico also came close, but neither side could earn a victory.
“The team is heading into Thursday’s game really well,” Simeone said. “We made important changes and the players responded. I had to rotate to ensure we had fresh players.”
In a mostly-empty stadium at Canary Islands, Munir El Haddadi struck twice with Alvaro Medran and Ruben Sobrino also netting as four second-half goals from Alaves consigned Las Palmas to relegation.
Paco Jemez’s side have 21 points from 34 games and are 13 short of Levante in 17th with only four matches left and they will join bottom side Malaga in the second division next season.
“Beyond the fact that this is a sad day, because we go down to the second division, it’s also sad because of the result. We went down in the worst way possible,” said Jemez.
“We are as sad as (the fans). We didn’t want this moment to arrive but we will keep working because there are still a lot of things to fight for.
“We must be responsible with the image of the club.”
Alaves’ triumph confirms their safety, sitting 13th with 41 points from 34 games.
It is an impressive feat masterminded by Abelardo Fernandez who took over in December with the Basque side bottom of the table.
Malaga beat Real Sociedad 2-0 and Espanyol won 2-0 at Girona to damage their Catalan rivals’ dreams of finishing in a Europa League spot.
The result left Girona ninth and Espanyol 16th in the standings, 11 points clear of the relegation zone.
Las Palmas have gone 12 matches without a victory and this was their fifth straight defeat.