Defending Serie A champions, Juventus, will seek continue their march to their eighth successive league title by opening up an 11-point lead when they host relegation-threatened Frosinone on Friday.
The match will be exclusively broadcast live on SuperSport 8 and SuperSport Select 5 at 8.30pm.
Frosinone, who are second from bottom, having lost 13 matches, will face the fire of superstar Juventus striker, Cristiano Ronaldo.
They can, however, take encouragement from their Juve’s 3-3 home draw against Parma as well as from winning their last two away matches.
Second-placed Napoli will seek to close the gap on the league leaders when they host Torino comes visiting the San Paolo Stadium.
The Gli Azzurri are still smarting from their underwhelming goalless draw with Fiorentina, who are in a good position to qualify for a continental competition.
The match is live on Sunday at 8:30pm on SuperSport 8 and SuperSport Select 5.
The battle for the fourth and final UEFA Champions League spot will intensify when fourth-placed AC Milan are hosted by fifth-placed Atlanta.
The encounter is live at 8:30pm on SuperSport 8 and SuperSport Select 5 on Sunday.
Despite a stuttering campaign, Milan, under their former star, Gennaro Gattuso, have stayed in the top half of the table.
They will, however, face Atalanta, who are unbeaten in their last eight games across all competitions and tend to score goals for fun.
Also on Saturday, Cagliari will square up with Parma.
The match is live at 6pm on SuperSport 8 and SuperSport Select 2 and 5.
On Sunday, SPAL take on Fiorentina (showing at 12 noon on SuperSport 8 and SuperSport Select 5; Udinese take on Chievo (showing at 3 pm on SuperSport 12; Genoa vs Lazio (showing at 3 pm on SuperSport 5); Empoli vs Sassuolo (showing at 3 pm) and Inter Milan vs Sampdoria (showing at 6 pm), both on SuperSport 8 and SuperSport Select 5.
On Monday, Roma and Bologna clash at the Stadio Olimpico (showing at 8:30pm on SuperSport 8).
All the matches are exclusive to DStv Premium, Compact Plus, Compact and GOtv MAX subscribers.